When to go: The best I would say is end of March or early April. You can see cherry/sakura blossoms. Plus, the weather is super nice.
Accommodation: You can choose either business style hotel or ryokan (Japanese inn where you sleep on tatami on the floor). I chose a hotel cause the location of most ryokans are in the outskirt of the city. It's still accessible by subway and bus (and taxi of course) but consider your luggage and level of comfort for yourself.
Transportation: Subway system in Tokyo is super complex. You have to know which station you are getting off, which subway line you have to take (sometime there;s more than 1 subway lines going to the same station), and which exit. You see from itinerary I always wrote the station I got off, what subway line I took and which exit. If you take the wrong exit you could end up 3 km away from your destination. To go around Tokyo, I suggest to buy SUICA card. I have written a note for you in my itinerary about this card. Check their website!
Meals: Food can be expensive if you don't know where to eat. Avoid eating at restaurants in hotels or along business/entertainment districts . I enjoyed eating in small noodle restaurants or food court in a shopping mall. Or you can always buy bento box from any convenience store (their convenience stores are really convenient! They carry everything you nee). Honestly, you can get by with onigiri (rice ball sold in convenience store). What I did for my breakfast, I bought cereals and milk from conv. store, that's about it
Point of interests: See my itinerary. But I add more interesting places for you to consider. I didn't visit them either because I had visited them before or I have no interest or I just didn't have enough time.
1. Tokyo Disneyland
2. Tokyo Tower -Shiodome
3. Zozoji Temple - Shiodome
4. Nihombashi
5. Tokyo Metropolitan Government building Shinjuku
6. Electric street - Shinjuku (your husband may find it interesting. it's heaven for camera lovers)
7. Yoyogi Park - Shibuya
8. Azabu Juban shopping town - Ropponggi
9. Akihabara
10. National Diet Building
11. Tokyo Dome: http://www.tokyo-dome.co.jp/e/park/
12. Kamakura area
13. Fujikyu Highland (this is out of Tokyo but you can go there by tour bus, see below)
If you're considering excursions out of Tokyo: check this http://www.jtbgmt.com/sunrisetour/index.aspx
For more information on Japan tourism: www.infomapjapan.com
For Tokyo tourism: www.tourism.metro.tokyo.jp
I think that's all for now. If I remember anything else...I'll let you know. Have fun planning!!!!